Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness

• Status: Completed
• Trial end date: 2022-04-30
• Target enrollment: 0
• Participant gender: Female

Summary

One hundred thirty women with unexplained infertility participated in a prospective clinical study. Patients were assigned at random to one of two groups. The first group (n=65) served as the study group and was given clomiphene citrate 50 mg (Tecnovula®, Techno Pharmaceuticals, Egypt) and sildenafil (Respatio®, Pharma right group, Egypt) 20 mg tablets. The second group (n=65) served as a control and received a placebo tablet in addition to the standard treatment of clomiphene citrate 50 mg (Tecnovula®). A transvaginal ultrasound was performed on all of the patients to assess ovulation.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Beni-Suef University
• Treatments: Citric Acid; Clomiphene; Enclomiphene; Sildenafil Citrate; Sodium Citrate; Zuclomiphene

Criteria

Inclusion Criteria:

• ages of 18 to 40

• patent tubes

• unexplained infertility

• regular menstrual cycle

• husband with normal sperm parameters

Exclusion Criteria:

• hypotension

• cardiovascular, renal and hepatic diseases

• uncontrolled diabetes mellitus

• anovulatory infertility

• abnormal thyroid functions

• ovarian cysts

• patients taking nitrates

• pelvic adhesions

• abnormal hormonal profile.

• hyperprolactinemia

• multiple uterine fibroids

• adenomyosis and endometriosis suspicion