Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients
Status:
Recruiting
Trial end date:
2020-09-30
Target enrollment:
Participant gender:
Summary
Lichen planus is an auto-immune, chronic inflammatory disease that affects mucosal and
cutaneous tissue. Erosive and atrophic oral lichen planus (OLP) are difficult to manage
because patients present with symptoms ranging from episodic pain to severe discomfort and
they have the highest malignant transformation rate (MTR) amongst all the forms of OLP. Zinc
is associated with regeneration of epithelium, wound healing and mediating T-lymphocyte
function; all of which can lead to healing and re-epithelisation in the lesions of erosive
OLP. Besides this, it also has anti-oxidant and anti-inflammatory properties, which lead to
decrease in apoptosis and transformation into a malignant state.
This study intends to evaluate the effect of oral zinc supplements as an adjuvant to the
topical corticosteroid therapy in the treatment of OLP.