Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients scheduled for primary total hip replacement needs postoperative pain treatment: i.e. morphine. Unfortunately morphine has side-effects: nausea, vomiting, sedation and dizziness, which is unpleasant for the patients and sometimes keeps them at bed longer time than needed. We investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine and improve the patients pain score after operation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Glostrup University Hospital, Copenhagen
• Treatments: Acetaminophen; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Pregabalin

Criteria

Inclusion Criteria:

• Patients scheduled for primary total hip replacement in spinal anaesthesia

• between the age of 55 and 75,

• ASA 1-3, and with

• BMI between 18 and 35.

Exclusion Criteria:

• are unable to cooperate;

• does not speak Danish;

• has allergy for drugs used in the trial;

• has drug and/or medicine abuse;

• epilepsy;

• diabetes treated with medicine;

• treatment with systemic steroids within 4 weeks prior to the operation;

• daily use of antacids;

• daily use of analgesics except for NSAID, Cox2 inhibitors and Paracetamol;

• known kidney disease;

• use of antidepressants