Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients Having a Tonsillectomy

• Status: Terminated
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients scheduled for a tonsillectomy need postoperative pain treatment. Some of the most widely used postoperative analgetics (NSAIDs) sometimes cause rebleeding in the postoperative period, and another often used analgetic, morphine, causes nausea and vomiting. The researchers therefore will investigate new combinations of postoperative analgesics in hopes of improving pain and the need for opioids during the postoperative period.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Glostrup University Hospital, Copenhagen
• Treatments: Acetaminophen; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Pregabalin

Criteria

Inclusion Criteria:

• Patients scheduled for benign tonsillectomy

• Between the ages of 18 and 50 years old

• ASA 1-2 and a surgical technique without the need for local anaesthetics or electrical scissors

Exclusion Criteria:

• Malignancy

• Patients who are unable to cooperate

• Does not speak Danish

• Has allergy for drugs used in the trial

• Has abused drugs and/or medicine

• Epilepsy

• Diabetes treated with medicine

• Treatment with systemic steroids 4 weeks prior to the operation

• Daily use of antacids

• Daily use of analgesics

• Use of antidepressives

• Known kidney disease

• Pregnancy