Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment

• Status: Recruiting
• Trial end date: 2022-12-18
• Target enrollment: 0
• Participant gender: All

Summary

Due to the high prevalence of malocclusions in Mexico and the existing concern to improve aesthetics, function (chewing), or both, patients resort to orthodontic treatment. The patient may experience pain during treatment due to the release of different chemical mediators such as RANK-L. Analgesic and anti-inflammatory medications such as acetaminophen and ketorolac are used to control pain during orthodontic tooth movement. These drugs can inhibit the expression of RANK-L which can affect tooth movement, inhibiting bone remodeling. The orthodontist should indicate the drug that is safest for the patient without affecting treatment or tooth movement.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Guadalajara
• Treatments: Ketorolac

Criteria

Inclusion Criteria:

• Patients of both sexes between 18 and 27 years of age

• Periodontally and systematically healthy

• Attended the Orthodontic Clinic of the University of Guadalajara

• Who required the use of dental spacers in at least one quadrant were included

Exclusion Criteria:

• Patients who have previously had orthodontic treatment or are under orthodontic treatment

• Who have an allergy to ketorolac or paracetamol

• Who are under pharmacological treatment and/or using contraceptives

• Pregnant or lactating women, as well as those who consume alcohol were not included or tobacco.