Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment
Status:
Recruiting
Trial end date:
2022-12-18
Target enrollment:
Participant gender:
Summary
Due to the high prevalence of malocclusions in Mexico and the existing concern to improve
aesthetics, function (chewing), or both, patients resort to orthodontic treatment. The
patient may experience pain during treatment due to the release of different chemical
mediators such as RANK-L. Analgesic and anti-inflammatory medications such as acetaminophen
and ketorolac are used to control pain during orthodontic tooth movement. These drugs can
inhibit the expression of RANK-L which can affect tooth movement, inhibiting bone remodeling.
The orthodontist should indicate the drug that is safest for the patient without affecting
treatment or tooth movement.