Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
This prospective, double blind, placebo-controlled, parallel group study will be conducted in
the first affiliated hospital of Sun yat-sen university in Guangzhou, China. Patients aged
18-65 (ASA I-II) undergoing elective gynecologic laparoscopic surgery with general anesthesia
will be involved in this study. According to previous studies and our pilot trial, estimated
120 patients will be involved in this study. All eligible patients will be randomly assigned
to two groups. In group P, patients will receive parecoxib 40mg intravenously 30min before
intubation, 8h and 20h after the surgery,respectively. In Group C, patients will receive
normal saline at the same time points. The shoulder pressure pain thresholds will be measured
with a pressure algometer by an independent doctor blinding to medication and grouping at the
day before surgery, 24h and 48h after surgery. Moreover, the intensity of shoulder pain and
side effects will be evaluated by another independent doctor at 24h and 48h after surgery. At
the end of the observation, the intensity of the maximal shoulder pain will be assessed.