Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease
Status:
Completed
Trial end date:
2006-05-01
Target enrollment:
Participant gender:
Summary
COAT-platelets stands for collagen and thrombin stimulated platelets, which are two things in
the body that make platelets stick together. These platelets may be important in the
initiation of a heart attack (myocardial infarction). A chemical in the body called serotonin
maybe responsible for COAT-platelet production. Paroxetine causes a significant reduction in
platelet serotonin and therefore may have value in preventing heart attacks. Therefore, the
current study is designed to determine whether paroxetine will decrease COAT-platelet
production in normal volunteers and patients with cardiovascular disease.