Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome

• Status: Recruiting
• Trial end date: 2021-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to investigate the effect of pentoxifylline administration on the status of endothelial function and oxidative stress biomarkers in patients with Acute Coronary Syndrome (ACS).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• Patients aged 18-80 years old.

• Recent ACS diagnosed-patients within the past 2 weeks.

Exclusion Criteria:

• Known allergy to pentoxifylline

• Heart failure New York Heart Association (NYHA) class III or IV

• Severe Left Ventricular Dysfunction (left ventricular ejection fraction <30%)

• High Serum creatinine level ≥ 2 mg/dl

• Liver disease (baseline alanine transaminase >2.5 times the upper limit of normal)

• Active bleeding or bleeding diathesis

• Major surgery or trauma within 1 month

• Recent cerebral and/or retinal hemorrhage within 3 months