Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Acute postoperative pain is an unpleasant, unwanted sensory and emotional experience for the patient. The investigators seek to determine if the addition of systemic lidocaine can improve the quality of recovery after spine surgery and reduce the requirement for opiate therapy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baylor College of Medicine
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

1. Patients age 18-80 yrs;

2. American Society of Anesthesiology Physical Status I, II or III; and

3. Patients undergoing thoracic or lumbosacral spine surgeries with or without instrumentation via the posterior approach with planned admission to the post anesthesia care unit after surgery-

Exclusion Criteria:

1. Allergy to any of the study medications or anesthetic agents used in the study;

2. American Society of Anesthesiology physical status IV;

3. Spine surgery with the expected duration of surgery being more than 4 hours as determined by the attending surgeon;

4. History of severe hepatic dysfunction with liver enzymes elevated to more than 3 times the normal or International normalized ratio of more than 2 and renal dysfunction with GFR less than 60 ml/min

5. History of previous spinal fusion or instrumentation;

6. Diagnosis of cancer of the spine;

7. History of surgery for abscess or osteomyelitis;

8. History of cardiac dysrhythmia or heart block;

9. History of chronic heroin or methadone use;

10. Preoperative use of any systemic corticosteroid;

11. History of seizure disorder; and

12. Patient inability to properly describe postoperative pain to investigators (dementia, delirium, psychiatric disorder).