Effect of Perioperative Oral Pregabalin in Total Knee Replacement

• Status: Recruiting
• Trial end date: 2025-07-30
• Target enrollment: 0
• Participant gender: All

Summary

This interventional randomized control trial aim to determine efficacy and safety of Oral pregabalin in improving after surgery pain control in patients undergoing total knee replacement surgeries under regional anesthesia. We'll compare the efficacy of pregabalin between two groups, pregabalin group and control group on the basis of their opioid consumption after knee operation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bahrain Defence Force Hospital
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

1. Age between 18 to 85 year

2. Elective Regional anesthesia.

3. Able to follow study protocol

Exclusion Criteria:

1. ASA -IV

2. Age <18 & > 85 years

3. Patients on pregabalin for chronic neuropathic pain.

4. Patient under General anesthesia

5. Patients with chronic liver failure

6. Patients with chronic renal failure on Hemodialysis

7. Patients on opioid (>3 month)

8. Patient with complicated knee surgery