Effect of Perioperative Short-term Iron Treatment on Allogenic Blood Transfusion

• Status: Not yet recruiting
• Trial end date: 2023-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to evaluate the effect of intravenous iron on perioperative anemia in elective non-cardiac major surgery patients with a history of ischemic heart disease by evaluating perioperative allogeneic red blood cell infusion. This study hypothesized that intravenous iron supplementation can reduce perioperative allogeneic red blood cell infusion and optimize perioperative anemia management.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Treatments: Epoetin Alfa; Ferric Oxide, Saccharated; Folic Acid; Hydroxocobalamin; Vitamin B 12; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• Over 18 years old

• Iron deficiency patients: ferritin <100µg/L and transferrin saturation <20%, with or without anemia (anemia: male hemoglobin (Hb) <130g/L, female hemoglobin (Hb) <120g/L)

• Patients with a history of ischemic heart disease were assessed by anaesthesia clinic (Include: history of myocardial infarction or current angina, positive exercise test, active chest pain after nitroglycerin use, pathological Q wave on ECG or PTCA/CABG)

• Major elective non-cardiac surgery: Abdominal surgery: radical resection of upper digestive tract and colorectal tumors, radical resection of pancreatic duodenal tumors, etc. Orthopedics: fracture trauma, large joint replacement, scoliosis correction, radical resection of bone tumor, etc.

Exclusion Criteria:

• There are contraindications and allergies to any kind of drugs

• Patients with body temperature >37.5 ℃ or using non-prophylactic antibiotics

• Pregnancy or lactation

• Weight 50 kg or less

• A history of organ transplantation or an imminent organ transplant

• Chronic liver disease and/or screening alanine/aspartate transferase higher than 3 times or more of the upper limit of the normal range

• Patients with chronic kidney disease dependent on hemodialysis

• Other known haematological diseases (hemolytic anemia, thalassemia, hemoglobinopathy, etc.)

• Severe anemia with preoperative hemoglobin <70g/L

• There was active bleeding before surgery

• Emergency surgery

• Critically ill patients with ASA≥4 before surgery

• Preoperative blood transfusion and history of similar drug use