Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The prevalence of portal vein thrombosis (PVT) in patients with liver cirrhosis is 5-20%. Current evidence regarding the effect of portal vein thrombosis on the prognosis of cirrhotic patients remains under debate. Considering that PVT potentially elevates the portal pressure and thereby increase the risk of variceal bleeding, we focus on the patients with high-risk varices and variceal bleeding as the study population. Thus, the main goals are to analyze the effect of PVT on the incidence of first variceal bleeding in patients without any prior bleeding history but with high-risk varices, the incidence of recurrent variceal bleeding in patients with a history of variceal bleeding, and the treatment failure rate of variceal bleeding in patients with acute variceal bleeding. Certainly, the survival is also observed in all patients.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Shenyang Military Region
• Treatments: Somatostatin

Criteria

Inclusion Criteria:

1. A diagnosis of liver cirrhosis.

2. Patients should be diagnosed with high-risk varices endoscopically, or a prior history of variceal bleeding, or an episode of acute variceal bleeding.

3. Patients agreed to undergo endoscopy to evaluate the presence and severity of varices.

4. Patients agreed to undergo contrast-enhanced CT scans to evaluate the portal vein patency. But if an abdominal contrast-enhanced CT scans was performed within 3 months after admission, it was not necessarily repeated.

Exclusion Criteria:

1. Non-cirrhotic patients.

2. Malignancy.

3. Contrast-enhanced CT scans were neither feasible nor available.

4. Severe cardiopulmonary diseases.

5. Severe infectious diseases.

6. Pregnant or breastfeeding.

7. Allergic to contrast agents.

8. Poor adherence.