Effect of Pre-emptive Dose of Prednisone Versus Placebo in Impacted Third Molar Surgery

• Status: Completed
• Trial end date: 2022-12-10
• Target enrollment: 0
• Participant gender: All

Summary

The present study proposes to compare the effect of a single preoperative dose of prednisone versus placebo in terms of facial swelling, trismus and pain after surgical removal of the mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Magna Graecia
• Treatments: Prednisone

Criteria

Inclusion Criteria:

• Patients aged 18 to 32 years who required both M3M extractions were recruited

• Good health status

• Indication to surgical extraction of both M3M

• Complete root formation

• Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification

Exclusion Criteria:

• Person under the age of 18 or over 32

• Allergy or contraindications to administration of corticosteroids

• Acute infection in any of the teeth to be extracted

• Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease

• Pregnancy or breastfeeding

• History of treatment with antiresorptive drugs

• Chronic kidney disease

• History of systemic corticosteroid therapy in the past 4 weeks