Effect of Pre-treatment With Magnesium Sulfate on the Duration of Deep Neuromuscular Blockade With Rocuronium
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
It is a prospective, comparative, randomized, double-blind clinical trial whose hypothesis is
that pre-treatment with magnesium sulfate, due to its action at the neuromuscular
junction,potentiate the duration of deep neuromuscular block following rocuronium
curarization in patients undergoing general anesthesia. Magnesium sulphate has gained
prominence as an adjuvant drug in anesthesia. Its use is associated with potentiation of
neuromuscular blockade among other functions.
The deep neuromuscular block is defined as the one obtained by the absence of response to the
sequence of four Stimuli and the presence of one or more simple stimuli in post-tetanic
counts . There is no literature description of the role of magnesium sulphate in Duration of
the deep neuromuscular block obtained after the muscle relaxation of patients with rocuronium
This study is justified because extending the clinical duration of neuromuscular blockers may
translate into gains for surgeries that require deep and long-lasting muscle relaxation as in
laparoscopic and robotic surgeries. This block allows lower inflation pressures of the
pneumoperitoneum to be obtained, as a result, there is a lower inflammatory and
cardiorespiratory repercussion for the patient