Effect of Preoperative Intravenous Fluid Infusion on Postoperative Complications

• Status: Not yet recruiting
• Trial end date: 2024-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia. Previous studies only focused on the hemodynamics after preoperative fluid infusion. Pre-operative fluid infusion can reduce the incidence of post-operative complications by preventing post-induction hypotension. The patients who is 18 years or older and undergo elective non-cardiac surgery with general anesthsia will be enrolled. The intervention is intravenous infusion of colloids or crytalloids before induction of general anesthesia. The primary outcome is the incidence of post-operative complications within 30 days.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xijing Hospital

Criteria

Inclusion Criteria:

• 18 years or older

• ASA I-III

• Undergoing elective non-cardiac surgery under general aneathesia

Exclusion Criteria:

• Allergic to colloids

• Severe heart diseases ( Ejection Fraction lower than 35%)

• Presence of renal failure pre-operatively (defined as creatinine >132 μg/L and/or patient receiving renal replacement therapy)

• Body mass index greater than 35 kg/m2

• Presence of a coagulopathy at screening (defined as platelet count < 100 × 109/L and/or a prothrombin time < 70% and/or an activated partial thromboplastin time (aPTT) >35 s and/or fibrinogen <1 g/ L)

• Presence of liver injury (defined as aspartate aminotransferase and/or alanine aminotransferase >80 IU/L)

• Pre-operative electrolyte disturbances with Na >150 mmol/L and/or Cl >110 mmol/L