Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
Status:
Not yet recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
Pregabalin is a structural analogue of gamma amino butyric acid (GABA). It binds to
presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the
spinal cord. Thus, it modulates the release of excitatory neurotransmitters, such as
glutamate, norepinephrine, substance-P, and calcitonin gene related peptide. Also, it causes
inhibitory modulation of overexcited neurons and restores them to a normal state.
Pre-emptive analgesia aims to reduce postoperative opioid consumption especially in
ambulatory surgeries. Pregabalin (PGB) is an emerging drug in this field. Different doses of
preoperative oral pregabalin (75, 150 and 300 mg) are described in the literature with a
dose-response analgesic relationship and reduction of opioid use; however increasing the dose
results in increasing the incidence of side effects mainly sedation and dizziness.
Perioperative use of opioids for analgesia may result in side effects; like nausea, vomiting,
excessive sedation, respiratory depression, pruritus, and urinary retention.The concomitant
use of opioids with pregabalin may result in excess sedation and somnolence, so, the use of
opioids with pregabalin should be limited to patients with inadequate alternative options.