Effect of Preoperative Pregabalin on Propofol Induction Dose

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Université de Sherbrooke
• Treatments: Pregabalin; Propofol

Criteria

Inclusion Criteria:

• Laparoscopic gynaecologic surgery

• Age 18-40 years

• ASA class I or II

• Body mass index 18-30

Exclusion Criteria:

• Allergic to pregabalin or gabapentin

• Chronic renal failure

• Alcohol or drug abuse

• Chronic analgesic use other than acetaminophen or NSAID

• Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug

• Known neurological deficiency

• Suspected difficult intubation or ventilation

• Atypical pseudocholinesterases