Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Lactobacillus reuteri-containing lozenges (Prodentis) are effective in treatment of halitosis in patients with chronic periodontitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zagreb
• Collaborator: BioGaia AB

Criteria

Inclusion Criteria:

• Adult patients, above age of 30

• Non-smokers or ex-smokers (not smoking in the past year)

• Moderate to advanced untreated chronic periodontitis

• Good compliance and following of oral hygiene instructions

• Halitosis in active phase and patient's subjective complaint

• Informed consent by the patient

Exclusion Criteria

• Aggressive periodontitis

• Antibiotics administered up to 3 months prior to this study

• Pregnancy and breastfeeding

• Immunosuppressive therapy

• Oral neoplasms (including radiation or chemotherapy)

• Diabetes mellitus

• Acute oral inflammation or infection

• Poor, unsatisfactory oral hygiene and lack of compliance

• Use of dietary supplements containing probiotics within 2 weeks prior to study start