Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species. The periodontal destruction is substantially mediated by the host, driven by the bacterial challenge. The presence of pathogenic bacteria with the absence of so-called "beneficial bacteria" and the susceptibility of the host are the main aetiological factors of periodontal diseases.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Next Gen Pharma India Pvt. Ltd.
• Collaborator: Krishnadevaraya College of Dental Sciences & Hospital

Criteria

Inclusion Criteria:

• Patients free from any systemic illness

• Previously untreated moderate to severe generalised chronic periodontitis.

• Patients free from adverse reactions to lactose or fermented milk products

• Patient unwilling to quit smoking and smokers over the past one year ( Smoker arm).

Exclusion Criteria:

• Previous history of antibiotic usage over past 6 months

• Patients who are eligible for antibiotic usage during the treatment course

• Patients who are pregnant, lactating, alcoholic or who had undergone any surgical or nonsurgical therapy within 6 months.

• Acute oral lesions or necrotising ulcerative periodontitis