Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis
Status:
Unknown status
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Background/Aims:
The investigators explored the therapeutic effects of probiotics in patients with AH.
Methods:
Between December 2012 and January 2015, the investigators conducted a 7-day,
double-controlled, randomized, prospective clinical trial comparing the efficacy of
probiotics in improving liver enzymes, LPS, pro-inflammatory cytokines, stool culture, and
stool Polymerase chain reaction denaturing gradient gel electrophoresis. AH was defined as an
aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2 and elevated AST (ALT)
level with an alcohol consumption history within 48 hours. Patients were randomized to
receive 7 days of cultured Lactobacillus rhamnosus R0011/acidophilus R0052 (120 mg/day) or
placebo. The levels of liver enzymes, modified Discriminant Function (mDF), LPS, and
pro-inflammatory cytokines, stool culture, and stool Polymerase chain reaction denaturing
gradient gel electrophoresis were checked at baseline and again after therapy.