Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes

• Status: Completed
• Trial end date: 2020-12-10
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of the study is to assess the efficacy of 17-hydroxyprogesterone caproate (17P) therapy on the latency period in pregnant women with Preterm premature rupture of membranes.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: 11-hydroxyprogesterone; 17 alpha-Hydroxyprogesterone Caproate; Castor Oil

Criteria

Inclusion Criteria:

• Singleton pregnancy

• Gestational age between 24 and 34 weeks

Exclusion Criteria:

• Medical or obstetric conditions that could put them at risk for uterine atony , postpartum hemorrhage AND infection, such as

• Emergency Cesarean section.

• Chorioamnionitis.

• Placenta previa.

• Multiple gestation.

• Preeclampsia.

• Macrosomia.

• Non reassuring fetal status or fetal distress

• Presence of fetal anomalies incompatable with life

• Woman with antepartum haemorrhage

• Diagnosis of Established preterm labor