Effect of Prolonged Sedation With Dexmedetomidine on Long-term Prognosis of Patients With Acute Ischemic Stroke After Mechanical Thrombectomy

• Status: Recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Dexmedetomidine can attenuate the activity of sympathetic nervous system under stress response and improve ischemia-reperfusion injury. The investigators hypothesized that the prolonged sedation of dexmedetomidine after thrombectomy may improve the clinical outcome of acute ischemic stroke patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Chao Yang Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• NIHSS≤25

• mRS score before stroke was less than 3

• Acute ischemic stroke (including anterior circulation)

• mTICI rate 2b or 3

• According to the 2018 AHA/ASA guidelines for the management of acute ischemic stroke, patients who plan to receive mechanical thrombectomy under local anesthesia and sedation

• Informed consent was signed by patient or legal representative

Exclusion Criteria:

• Intracerebral hemorrhage occurred in the responsible vessel area in the past 6 weeks

• Patients who had received stent treatment at the responsible vessel in the past

• Neurological function was restored at or before angiography

• Patients who are allergic to heparin, aspirin, clopidogrel, rapamycin, lactic acid polymer, poly (n-butyl methacrylate), stainless steel, anesthetics and contrast agents or have contraindications

• Hemoglobin was less than 70g/L, platelet count was less than 50×109/L, international normalized ratio (INR) greater than 1.5 (irreversible), there are uncorrectable bleeding factors

• Blood glucose < 2.7 mmol/L or > 22.2 mmol/L

• Severe liver or kidney disfunction, ALT>3 times the upper limit of normal value or AST>3 times the upper limit of normal value, creatinine>1.5 times the upper limit of normal value

• Pregnant or lactating women

• Previous history of mental illness

• Stroke with other acute diseases or postoperative stroke of other operation

• Heart rate less than 50bpm, second or third degree of atrioventricular block (except for pacemaker implantation), systolic blood pressure less than 90mmHg (two vasoactive drugs were already infused continuously )