Patients with primary knee osteoarthritis will be included in the study, plain X-ray for the
affected knee, followed by musculoskeletal ultrasound assessment will be done. The
intervention: intra-articular injection and extra-articular injections of 25% dextrose.
Follow up will be done at 24 weeks after the last injection both clinically and
ultrasonographically .
Aim: Determine whether prolotherapy improves pain. stiffness and function of symptomatic knee
osteoarthritis and determine ultrasonographic changes before and after prolotherapy.