Effect of Propofol-Dexmedetomidine on Cerebral Oxygenation and Metabolism During Brain Tumor Resection

• Status: Completed
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Despite theoretical benefits of intravenous agents, volatile agents remain popular. In a study comparing desflurane, isoflurane, and sevoflurane in a porcine model of intracranial hypertension, at equipotent doses and normocapnia, cerebral blood flow (CBF) and intra-cranial pressure (ICP) were least with sevoflurane.

Propofol is the most commonly used intravenous anesthetic. It has many theoretical advantages by reducing cerebral blood volume (CBV) and ICP and preserving both autoregulation and vascular reactivity. Neurosurgical patients anaesthetized with propofol were found to have lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane.

The well known pharmacodynamic advantages of intravenous anesthetics may give this group of drugs superior cerebral effects when compared with inhalation anesthetics.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Anesthetics; Dexmedetomidine; Fentanyl; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status III or IV.

• Patients scheduled for elective brain tumor resection

Exclusion Criteria:

• Morbid obese patients.

• Severe or uncompensated cardiovascular diseases.

• Severe or uncompensated renal diseases.

• Severe or uncompensated hepatic diseases.

• Severe or uncompensated endocrinal diseases.

• Pregnancy.

• Postpartum or lactating females.

• Allergy to one of the agents used.

• Severely altered consciousness level.

• Sitting position during surgery.

• Prone position during surgery,