Effect of Propofol and Desflurane on Nucleic Acid of Liver Circulating Tumor

• Status: Completed
• Trial end date: 2022-08-08
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the effects of perioperative anesthetic drugs propofol and desflurane on circulating tumor nucleic acids (CK7, ELF3, EGFR and EphB4 mRNA) in the blood of patients with liver cancer, so as to provide scientific reference for clinical anesthesia in the perioperative treatment of tumor

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhejiang Cancer Hospital
• Treatments: Desflurane; Propofol

Criteria

Inclusion Criteria:

• Age range: 18 to 75

• ASA: I-III

• primary liver cancer (CNLC: Stage I-IIIA)

• undergoing elective hepatectomy

Exclusion Criteria:

• Patients with severe bradycardia (HR < 55bpm)

• patients with severe arrhythmias or cardiac dysfunction (EF < 35%)

• patients with severe respiratory lung disease

• patients with severe liver and kidney insufficiency epilepsy

• patients with severe hyperlipidemia

• patients with a history of malignant hyperthermia

• patients with propofol or desflurane allergy

• patients with history of preoperative chemoradiotherapy

• patients who were on immunosuppressive treatment

• patients with chronic opioid therapy declined to participate in the study