Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Ischemia/reperfusion (I/R)-induced acute kidney injury is a serious complication affecting patient outcome following cardiovascular surgeries. Propofol, an intravenously administered anesthetic with antioxidant properties, protects organs from I/R injury. This study aimed to investigate the ability of propofol to protect kidneys against I/R injury in the patients undergoing valvular heart surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Patients undergoing valvular heart surgery.

• Age: 20~75.

Exclusion Criteria:

• Emergency operation.

• Patients with vitamin E or vitamin C within 5 days before surgery.

• Patients with preoperative C-reactive protein (CRP) > 16 mg/L.

• Patients with serum creatinine ≥ 2.0 mg/dL

• Patients under hemodialysis.

• Patients with acute myocardial infarction within 1 week before surgery