Effect of Proton Pump Inhibitor and Mosapride on Acid Pocket in Gastroesophageal Reflux Disease
Status:
Unknown status
Trial end date:
2018-07-01
Target enrollment:
Participant gender:
Summary
The gastric acid pocket is believed to be the reservoir from which acid reflux events
originate. The risk for acidic reflux is mainly determined by the position of the gastric
acid pocket. Little is known about how changes in position and size of the acid pocket
contribute to the therapeutic effect of proton pump inhibitors(PPI) plus mosapride in
patients with gastroesophageal reflux disease. Investigators will conduct a prospective
randomized, single blind and placebo-controlled clinical trial to evaluate the hypothesis
that mosapride affecting gastric motility might reduce gastro-esophageal reflux by changing
the acid pocket position and size.