Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery
Status:
Completed
Trial end date:
2021-06-10
Target enrollment:
Participant gender:
Summary
This randomized pilot phase I trial will evaluate if quercetin enhances the uptake of green
tea polyphenols in the prostate tissue of men taking green tea extract and undergoing radical
prostatectomy. Side effects of green tea extract and quercetin in combination with green tea
extract will also be evaluated. In preclinical studies, green tea polyphenols have anticancer
and cancer preventative effects in a number of malignancies. Likewise, in preclinical studies
quercetin was found to enhance the anticancer effects of green tea. This trial is designed to
translate these findings forward in a short-term human intervention trial.