Effect of Ramosetron on Heart Rate-corrected QT Interval During Robot-assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position

• Status: Completed
• Trial end date: 2020-06-12
• Target enrollment: 0
• Participant gender: All

Summary

Intraperitoneal insufflation of carbon dioxide may affect the sympathetic activity that leads to changes in ventricular re-polarization. This in turn can result in changes of heart rate-corrected QT (QTc) interval. Ramosetron is a 5-hydroxytryptamine three receptor antagonist and widely used anti-emetics. However, QTc interval prolongation has been observed in a number of patients after administration of 5-HT3 receptor antagonists. The aim of this study is to evaluate the effects of ramosetron on QTc interval and possible cardiovascular adverse effects during robot-assisted laparoscopic prostatectomy with steep Trendelenburg position.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Ramosetron

Criteria

Inclusion Criteria:

• Patients undergoing robot-assisted laparoscopic prostatectomy

• Age more than 19 years

Exclusion Criteria:

• Preoperative electrocardiography (ECG) abnormalities, including a QTc interval of >500 ms, ventricular conduction abnormalities, or arrhythmias

• History of cardiac disease such as pacemaker insertion, unstable angina

• Use of antiarrhythmic agents or medications that are known to prolong the QTc interval

• Abnormal levels of preoperative serum electrolyte