Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Insulin; Rasburicase; Uric Acid

Criteria

Inclusion Criteria:

• obese (BMI 30-45 kg/m²);

• serum UA concentration either ≥5 mg/dL or ≤4.0 mg/dL (297 µmol/L)],

Exclusion Criteria:

• renal dysfunction (serum creatinine >1.5 mg/dL);

• pregnancy or lactating;

• take urate-lowering agents, thiazide diuretics, prednisone or medications containing aspirin or other salicylates;

• history of xanthinuria, type 2 diabetes or other significant organ system dysfunction;

• have G6PD deficiency;

• use hormone-replacement or oral-contraceptive therapy;

• smoke tobacco;

• anemic (Hb <10 g/dl)