Effect of Regular Sildenafil on Blood Pressure and Arterial Function in Hypertension

• Status: Completed
• Trial end date: 2005-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to investigate if regular treatment with sildenafil reduces blood pressure and improves blood vessel function in patients with hypertension (high blood pressure).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Edinburgh
• Collaborator: Pfizer
• Treatments: Sildenafil Citrate

Criteria

Inclusion Criteria:

• Male or female

• Hypertensive (office systolic BP ≥160 mmHg or diastolic BP ≥100 mmHg), not taking antihypertensive drugs OR hypertensive controlled (systolic BP < 160 mmHg or diastolic BP < 100 mmHg) on 1 antihypertensive agent

• Hypertension confirmed on ambulatory monitoring (average daytime BP ≥145/95 mmHg)

• Patients will also be included if they have 'borderline' hypertension and their calculated 10-year risk of cardiovascular disease is >20% or they have target organ damage. Borderline hypertension will be defined according to ambulatory BP criteria alone (average awake systolic BP ≥135 and <145 mmHg or diastolic BP ≥85 and <95 mmHg).

Exclusion Criteria:

• History of other major cardiac, respiratory, neurological or renal disease

• Systolic BP consistently >210 mmHg or diastolic BP consistently >120 mmHg

• Systolic BP consistently >180 mmHg or diastolic BP consistently >110 mmHg in those withdrawn from existing therapy

• Current alcohol abuse

• Diabetes

• Taking vasoactive drugs

• Previous serious drug allergy

• Pregnant

• Participation, within 6 months, in other research studies