Effect of Remifentanil Boluses on Hemodynamics in Skull Pin Insertion

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Skull pin insertion during craniotomies is a brief, intensely stimulating, painful stimuli occurring during the conduct of a neurosurgical or spine anesthetic. Remifentanil is an ultra short acting opioid that has been successfully used to blunt hemodynamic responses in a wide variety of clinical scenarios. It is our intention to ascertain the optimal dose for blunting the hemodynamic response to skull pin insertion using remifentanil.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Health Network, Toronto
• Treatments: Remifentanil

Criteria

Inclusion Criteria:

Patients requiring skull pin fixation and general anesthesia for:

• Elective cervical spine surgery

• Elective craniotomies/brain tumor resection

• Elective transsphenoidal pituitary hypophysectomies

Exclusion Criteria:

Patients with evidence of raised intracranial pressure:

• GSC < 15

• Radiological evidence of significant rise in ICP (e.g. midline shift)

• Vascular anomalies in the brain