Effect of Remifentanil on Postoperative Cognition Function in Patients Undergoing Major Abdominal Surgery

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effects of two different analgesic methods (Fentanyl vs Remifentanil) during major abdominal surgery on postoperative cognitive status of patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Catholic University of the Sacred Heart
• Treatments: Acetaminophen; Anesthetics; Cisatracurium; Fentanyl; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Age over 60 years

• Patients undergoing major abdominal surgery, in General Anesthesia

• ASA class status I-III

Exclusion Criteria:

• History of allergy to drugs used in the study

• Mini-Mental State Examination (MMSE) value < 26

• Expected duration of anesthesia less than 1 hour and more than 4 hours

• Presence of a cognitive disorder severity of overt such as to prevent collaboration of the patient

• Presence of severe electrolyte disturbances or not controlled bool glucose levels

• History of pain or cerebral vascular disease on the basis of significant carotid or cerebral artery stenosis, to be verified by scanning eco-color doppler

• Habitual use of tranquillizers or other drugs affecting the central nervous system

• Difficulties in the management of the airways, such as to make the necessary changes in anesthesia technique

• Severe hypotension or hypertension or other vascular disorders, particularly thrombotic events or bleeding during surgery or in the perioperative period

• Bleeding that requires blood transfusion

• Medication needs higher or lower than that indicated in the protocol to ensure the depth of hypnosis, indicated by values of BIS targets

• Refusal by the patient