Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position
Status:
Recruiting
Trial end date:
2023-09-30
Target enrollment:
Participant gender:
Summary
Most of the major spinal surgeries are performed in the supine position, which causes a
decrease in stroke volume and cardiac index, which leads to the occurrence of hypotension
during surgery. Postoperative hypotension causes an imbalance in the supply and demand of
oxygen, leading to postoperative myocardial infarction or acute renal damage, and may
increase mortality one year after surgery. Propofol, which is most commonly used for total
intravenous anesthesia, can further increase the incidence of hypotension during surgery.
Therefore, there is a continuing demand for an anesthetic agent that is more hemodynamically
stable. Remimazolam, an ultra-short acting benzodiazepine that has a similar structure to
midazolam, but whose activity is terminated by esterase hydrolysis, is expected to have less
hemodynamic effects than propofol. Therefore, the purpose of this study is to investigate the
effect of general anesthesia using remimazolam and general anesthesia using propofol on
hemodynamic safety during surgery in patients undergoing major spinal surgery in the supine
position.