Effect of Repeated Administration of Liraglutide on Insulinogenic Indices

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The study investigates the effect of glucagon-like peptide receptor 1 agonist, liraglutide, on insulin secretion. Study hypothesis: the effect of liraglutide on insulin release may change after repeated administration. The effect of liraglutide on insulin release will be tested using graded glucose infusion test (GGIT) in healthy volunteers. GGIT will be performed without medication and repeated 12 hours after first dose of liraglutide and after 3 weeks of treatment with liraglutide.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Tartu
• Treatments: Liraglutide

Criteria

Inclusion Criteria:

• Weight 50-100 kg

Exclusion Criteria:

• Chronic disease

• Concomitant drug use

• Pregnancy or lactation

• Fasting glucose >6 mmol/L.