Effect of Replacement Volume of Haemodiafiltration and AST-120 on Toxins, Oxidative Stress and MicroInflammation
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
Accumulating evidence suggested that increased oxidative stress (OxSt) as well as
inflammation are risk factors for cardiovascular events in hemodialysis patients. The
incremental effect of online haemodiafiltration (OL-HDF) on markers of microinflammation ,and
OxSt is less clear. Besides, the relationship between protein-bind uremic toxin and
microinflammation remains obscure. The aim of this study was to evaluate the effect volume
replacement of on-line hemodiafiltration on proinflammatory peripheral monocytes (percentage
of CD14+CD16+ cells), PAF, IL-6 and on the plasma level of several oxidative stress markers
as well as several protein-bound uremic toxins such as p-cresol, indole sulfate etc. In a
case controlled study, 30 patients on OL-HDF will be evaluated. The association between
protein-bound uremic toxins such as p-cresol, indole sulfate etc and AST-120, a spherical
adsorptive carbon preparation (Kremezin) will also being investigated.