Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children

• Status: Completed
• Trial end date: 2019-05-19
• Target enrollment: 0
• Participant gender: All

Summary

Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above. Although it has been in use over the last 10 years, more pharmacological studies are needed to understand its overall effects on participants.

As investigators' primary outcome, the investigators aimed to investigate how differently sugammadex reverses neumuscular blockade caused by rocuronium under general anesthesia maintenance with sevoflurane compared with desflurane. Also, to compare the changes in peak airway pressure. As investigators' secondary outcome, the investigators aimed to compare the changes in heart rate and blood pressures after sugammadex injection under sevoflurane and desflurane general anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Istanbul University
• Collaborators: Ayse Cigdem Tutuncu; GAMZE PİRİNÇ ŞAŞIOĞLU; GÜNER KAYA
• Treatments: Anesthetics; Desflurane; Isoflurane; Rocuronium; Sevoflurane

Criteria

Inclusion Criteria:

• Lower urinary tract surgery (cystoscopy, examination under general anaesthesia, circumcision etc.) and inguinal hernia surgery expected no to last more than 2 hours

• ASA I-II

Exclusion Criteria:

• Liver and failure

• Upper airway infection

• Asthma

• Exposure to second hand smoke

• Kidney failure

• Obesity (BMI> 30%)

• Rocuronium allergy

• Muscle disease (myasthenia gravis, muscular dystrophies, etc.)

• Calcium channel blocker use

• Patient or family refusal