Effect of Rosuvastatin in Abdominal Sepsis

• Status: Unknown status
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether rosuvastatin is effective as a coadjuvant drug in the integral management of abdominal sepsis acknowledged by surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidad Autonoma de San Luis Potosí
• Treatments: Rosuvastatin Calcium

Criteria

Inclusion Criteria:

1. Man or women > 18 and < 80 years old with abdominal sepsis, confirmed diagnosis by surgery of broad peritonitis before 48 hours in progression

2. Injury by steel or firearm with contaminated abdominal cavity

3. APACHE II major or equal than 8

4. Acceptance to be included

Exclusion Criteria:

1. Ingestion of: fibrates, niacin, cyclosporin, azoles, macrolides, inhibitors of protease, nefazodone, verapamil, diltiazem, amiodarone

2. Hypovolemic shock III and IV after get surgery

3. Cardio-respiratory failure pre or trans surgery

4. Allergy to used drug

5. Use previous of statin

6. Hepatopathy or myopathy and(or) history, hepatic failure (Child B y C)

7. Management in other Hospital

8. Pregnancy

9. Thoracic injury, head injury (moderate and severe), multiple fractures or with bone exposition, rectal injury