Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome
Status:
Completed
Trial end date:
2017-06-23
Target enrollment:
Participant gender:
Summary
Several studies report association between restless legs syndrome (RLS), HTA and
cardiovascular diseases .
The mechanisms involved in this relationship remained unknown, but several evidences favor
the role of periodic limb movements in sleep (PLMS), patterns frequently associated with RLS.
Sympathetic overactivity is associated with PLMS with increased pulse rate and blood pressure
coincident with PLMS. PLMS-related repetitive nocturnal blood pressure fluctuations could
contribute to the risk of high blood pressure, heart disease, and stroke in patients with
RLS, especially in the elderly. Several studies already reported that dopaminergic agonists
reduce the severity of RLS and the PLMS index.
Do dopaminergic agonists reduce the risk of cardiovascular diseases and associated autonomic
dysfunctions in patients with RLS ?
Nocturnal BP (blood pressure) decline has major clinical implications, and the loss of normal
reduction in BP during sleep is associated with high risk of cardiovascular morbidity and
mortality.
The main aim of this study was to evaluate the impact of rotigotine patch treatment on
validated cardiovascular risk factors ambulatory BP during night, day and night-to-day ratio,
and endothelial function in patients with idiopathic RLS compared to placebo.