Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery

• Status: Recruiting
• Trial end date: 2023-10-30
• Target enrollment: 0
• Participant gender: All

Summary

This study is a randomized, double-blinded, controlled design. In this study, low doses of S-ketamine were selected for surgury treatment in septic patients under general anesthesia , Meanwhile, activity of HO-1 protein , oxidative stress and inflammatory markers in serum are measured to evaluating the effects of S-ketamine Anesthetic on inflammatory response in septic patients undergoing abdominal surgury. In addition,It is very necessary to make use of the advantages of low-dose S-ketamine in anti-inflammation, and avoid the side effects of mental symptoms, so as to guide the new direction of perioperative clinical application of S-ketamine.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tianjin Nankai Hospital
• Treatments: Esketamine; Ketamine

Criteria

Inclusion Criteria:

• Patients with sepsis requiring surgical treatment under general anesthesia should be transferred to ICU with endotracheal intubation for further treatment after surgery

• 18≤ age ≤85, gender and nationality is not limited

• Agree to participate in this study and sign the informed consent

Exclusion Criteria:

• Declined to participate in this study

• Patients in pregnancy or with drug allergy in this study

• Patient had chronic or acute respiratory ailments

• long-term preoperative continuous ventilatory support or oxygen dependency

• Patients are now being included in another study

• In the opinion of the attending physician or researcher, there are other conditions that are not appropriate for the study