Effect of S-ketamine in Cesarean Section Combined Anesthesia

• Status: Not yet recruiting
• Trial end date: 2023-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

To compare the anti-hyperalgesia effect between S-ketamine with placebo for Maternal receiving elective Cesarean Section under Combined spinal and epidural analgesia.

Based on this study the investigators intend to verify the role and potential mechanism of S-ketamine combined anesthesia in alleviating hyperalgesia after cesarean section, prove that it can reduce hyperalgesia and postoperative pain. explore the role of S-ketamine in alleviating postoperative hyperalgesia in different PCA ways and explore the safety of S-ketamine in the perilactation

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University
• Treatments: Esketamine; Ketamine

Criteria

Inclusion Criteria:

• ASA status I-III

• Age 20 to 45

• 37-42 weeks gestation

• undergo elective cesarean section with subarachnoid anesthesia

• participate in this study and sign informed consent

Exclusion Criteria:

• Patients with contraindications for cesarean section

• Patients with contraindications of combined spinal and epidural anesthesia

• Patients with severe systemic disease

• Alcoholism and long-term use of anti-inflammatory and analgesic drugs

• Patients who were unable to cooperate or refused to participate in the trial

• Patients with contraindications to esketamine and hydromorphone