Effect of Sedation on Intra-abdominal Pressure

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of deepening of sedation on intra-abdominal pressure in mechanically ventilated adult patients with intra-abdominal hypertension.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tartu University Hospital
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Age 18 years or older

• Mechanical ventilation

• IAP between 12 and 20 mmHg in at least two consecutive measurements within 1-12 h

• Spontaneous breathing activity of at least 6 breaths/minute

• RASS score between 0 and -4

• Physician-led sedation (if sedated; as opposed to nurse-led protocol)

Exclusion Criteria:

• Contraindication for propofol administration

• Contraindication for IAP measurement in supine position with head-of-bed at 0°

• Other intervention for reduction of IAP planned

• Previous propofol infusion rate >4 mg/kg/h