Overview
Effect of Serotonin and Levodopa in Ischemic Stroke
Status:
Completed
Completed
Trial end date:
2019-10-31
2019-10-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
Cortical plasticity plays a pivotal role in functional recovery after a stroke. Neurotransmitter release, facilitates the creation of new synapses and promotes brain plasticity. In a pilot study, will evaluate the potential benefit of drugs that increase the release of neurotransmitters in patients with first stroke.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Hospital de GranollersTreatments:
Carbidopa
Carbidopa, levodopa drug combination
Citalopram
Dexetimide
Levodopa
Serotonin
Criteria
Inclusion Criteria:- • Patients with a first stroke with NIHSS 5-20 points
- Patients without aphasia to avoid interference in the assessment of depression
and cognitive impairment
- Patients with independent functional status prior to stroke (mRS <3)
- Patients without prior cognitive impairment or depressive syndrome assessed by
medical history with the patient and family.
- The assigned treatment initiated within the first five days of stroke
Exclusion Criteria:
- • Patients with prior myocardial or cerebral hemorrhage
- Patients with TIA
- Patients with aphasia
- History of cognitive impairment or prior depressive syndrome
- Patients with no independent functional status mRS greater than or equal to 3
- Underlying disease hopefully less than one year of life.
- Patient pre-treatment with levodopa, an antidepressant or neuroleptic.