Overview

Effect of Serotonin and Levodopa in Ischemic Stroke

Status:
Completed
Trial end date:
2019-10-31
Target enrollment:
0
Participant gender:
All
Summary
Cortical plasticity plays a pivotal role in functional recovery after a stroke. Neurotransmitter release, facilitates the creation of new synapses and promotes brain plasticity. In a pilot study, will evaluate the potential benefit of drugs that increase the release of neurotransmitters in patients with first stroke.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hospital de Granollers
Treatments:
Carbidopa
Carbidopa, levodopa drug combination
Citalopram
Dexetimide
Levodopa
Serotonin
Criteria
Inclusion Criteria:

- • Patients with a first stroke with NIHSS 5-20 points

- Patients without aphasia to avoid interference in the assessment of depression
and cognitive impairment

- Patients with independent functional status prior to stroke (mRS <3)

- Patients without prior cognitive impairment or depressive syndrome assessed by
medical history with the patient and family.

- The assigned treatment initiated within the first five days of stroke

Exclusion Criteria:

- • Patients with prior myocardial or cerebral hemorrhage

- Patients with TIA

- Patients with aphasia

- History of cognitive impairment or prior depressive syndrome

- Patients with no independent functional status mRS greater than or equal to 3

- Underlying disease hopefully less than one year of life.

- Patient pre-treatment with levodopa, an antidepressant or neuroleptic.