Effect of Simethicone on Bowel Preparation for Colonoscopy
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
Optimal bowel preparation is essential for colonoscopy efficacy and safety. Mucosal
visualization during colonoscopy is often limited by residual stool, bubbles, bile,
intraluminal fluid, and debris, which increase the risk of missing flat adenomas or other
small lesions.Therefore, intestinal preparation is necessary to remove residual materials
prior to endoscopy.
A combined agent, low-dose PEG with ascorbic acid (PEG-Asc), is one low-volume solution
commonly used in Korea (Coolprep®; TaeJoon Pharmaceuticals, Seoul, Korea). However,
practitioners have noted an increased incidence of bubble formation with this preparation
method.
To the investigators knowledge, no previous study has assessed colon preparation in patients
administered simethicone.
The purpose of this study was to compare the quality of bowel preparation and compliance
between PEG-Asc and PEG-Asc with simethicone. The effectiveness of adding simethicone as an
antifoaming agent to improve bowel cleansing for colonoscopy was evaluated in terms of bowel
preparation scale and bubble score, and the compliance of both patients and endoscopists was
also investigated using a questionnaire.