Effect of Single Dose Intranasal Insulin On Cognitive Function
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to find out how a small dose of insulin might affect memory, the
ability to concentrate, and improve your daily functioning in patients with schizophrenia and
schizoaffective disorders. Insulin is not being used to treat diabetes in this study. The
investigators propose a single dose, double-blinded, placebo-controlled trial of intranasal
insulin in 40 subjects with schizophrenia or schizoaffective disorder to examine insulin's
effect on cognition. The specific aims include:
1. Examine the effects of single doses of 40 IU intranasal insulin compared to placebo on
cognitive functioning, including attention and memory.
2. Examine whether single dose of intranasal insulin administration will raise serum
insulin level and decrease plasma glucose level
Insulin will be delivered through an air spray pump into your nose. The investigators will be
comparing one dose of insulin (40 International Units) with placebo, an inactive liquid.