Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D

• Status: Completed
• Trial end date: 2021-08-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this interventional study is to assess the effect of the single high dose of vitamin D on its serum metabolites in elderly.

The main questions it attempts to answer is:

1. what is the effect of a single, high, oral dose of vitamin D3 (120,000 IU) on serum 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, 3-epi-25(OH)D3, 1,25(OH)2D3, 24,25(OH)2D3/25(OH)D3 ratio, and 25(OH)D3/3-epi-25(OH)D3 ratio concentration at baseline, 3 days and 7 days after administration, compared to control group.

2. what is the influence of percentage of fat tissue on serum metabolites of vitamin D and their changes after bolus dose, compared to control group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Department of Endocrinology, Centre of Postgraduate Medical Education
• Treatments: Cholecalciferol; Vitamin D

Criteria

Inclusion Criteria:

• written, informed consent,

• age ≥ 60 years-old,

• admission to the hospital due to emergency reasons.

Exclusion Criteria:

• hypercalcemia,

• nephrolithiasis,

• kidney insufficiency,

• documented vitamin D3 metabolism disorders such as sarcoidosis, parathyroid disease or genetic defects,

• vitamin D3 supplementation within 6 months prior to the hospitalisation.