Overview

Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy

Status:
Completed

Trial end date:
2013-06-01

Target enrollment:
0

Participant gender:
All

Summary

Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. Post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. Dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia. In this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Yonsei University

Treatments:

Dexmedetomidine

Criteria

Inclusion Criteria:

- ASA physical status 1 or 2 patients patients scheduled for thyroidectomy

Exclusion Criteria:

- Severe cardiovascular disease history of motion sickness active status of upper
respiratory infection allergy to dexmedetomidine patients who cannot understand Korean