Effect of Sitagliptin on Graft Function Following Islet Transplantation
Status:
Terminated
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
Islet transplantation requires a large number of islets required to achieve insulin
independence and the function of the transplanted islets progressively declines over time.
Evidence from animal studies and human islets in culture suggests that increasing GLP-1
levels could help with both of these problems. This study is designed to test this hypothesis
using sitagliptin in a randomized clinical trial.
Phase:
Phase 3
Details
Lead Sponsor:
University of British Columbia
Collaborator:
Merck Sharp & Dohme Corp.
Treatments:
Dipeptidyl-Peptidase IV Inhibitors Sitagliptin Phosphate