Effect of Solanum Melongena Extract in the Treatment of Arsenical Skin Lesion

• Status: Completed
• Trial end date: 2017-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Solanum melongena is a common vegetable contains phytochemicals which prevent, reduce or delay the oxidation of DNA and alter the cellular signal transduction pathways controlling cell proliferation and apoptosis of human cancer. The skin of Solanum melongena peel contains nasunin an anthocyanins and chlorogenic acid which have anti-inflammatory, antioxidant, antimutagenic and antiangiogenic properties. Extract of Solanum melongena is used in actinic keratosis and Squamous cell carcinoma of the skin. This study will determine any change in arsenical skin lesion after administrating Solanum melongena extract cream.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Criteria

Inclusion Criteria:

• Age: 18-60 years

• Sex: Both male and female

• Arsenicosis: Severe arsenical skin lesions with Bowen's disease or Squamous cell carcinoma

• Drinking arsenic contaminated water (> 50 µg/L) for more than 6 months

• Patient voluntarily agreed to participate

• Patient who understood the instruction of applying medicine and apply it as he or she will be instructed

Exclusion Criteria:

• Age: Less than 18 and above 60 years

• Expectant, Pregnant and lactating mother

• Major health problems Tuberculosis, Hepatic diseases, Renal diseases, Systamic lupus erythrometosis,

• Rheumatoid arthritis

• Patient with other skin diseases like ectopic dermatitis, psoriasis, eczema, drug allergy

• Food allergy of Solanum melongena

• Patient who received treatment within last three months

• Patient with Bowen disease and Squamous cell carcinoma due to other cause

• Patient did not voluntarily agree to participants