Effect of Statin Preloading in STEMI in Improving PCI Outcomes

• Status: Recruiting
• Trial end date: 2022-04-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effect of a single high dose of atorvastatin versus rosuvastatin preloading on microvascular coronary perfusion as determined by CTFC in patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beni-Suef University
• Treatments: Atorvastatin; Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• The Presence of symptoms (<12h).

• ST-segment elevation of at least 0.1Mv in two contiguous leads of electrocardiogram or new onset left bundle branch block.

• Patients age 18 to 80 years.

Exclusion Criteria:

• Previous (within 3 months) or current treatment with statins.

• Known allergy to heparin, aspirin, clopidogrel, or abciximab.

• Active severe bleeding.

• Pregnancy.

• History of major surgery or trauma.

• Significant gastrointestinal or genitourinary bleeding (<6 weeks).

• History of cerebrovascular attack (within 2 years) or cerebrovascular attack with a significant residual neurological deficit.

• Cardiogenic shock with mechanical ventilation.